5 Amino 1mq Canada

5-Amino-1MQ Canada (5-amino-1-methylquinolinium), a small-molecule NNMT inhibitor studied for NAD+ salvage pathway modulation, cellular metabolic regulation, and adipocyte bioenergetics. Note: 5-Amino-1MQ is a quinolinium compound, not a peptide. 10mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

5-Amino-1MQ is a small-molecule quinolinium compound — not a peptide — that selectively inhibits nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme involved in the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. NNMT is overexpressed in adipose tissue and certain metabolic contexts. By inhibiting NNMT, 5-Amino-1MQ has been shown to increase intracellular NAD+ and SAM availability, upregulate polyamine flux enzymes, and alter histone methylation patterns in preclinical adipocyte models. Durham Peptides also carries NAD+ for researchers studying NAD+ biology directly.

BENEFITS; 5-Amino-1MQ Canada

• Selective NNMT inhibition — substrate-site targeting with minimal off-target activity in preclinical models

• NAD+ salvage modulation — studied for increasing intracellular NAD+ and SAM availability

• Adipose metabolism — investigated for suppression of adipocyte lipogenesis in 3T3-L1 models

• Small molecule — distinct mechanism from peptide-based metabolic compounds (GLP-1 agonists, etc.)

• Defined pharmacology — IC₅₀ of 1.2 μM confirmed in published enzymatic assays

WHAT RESEARCHERS LOOK AT

• NNMT enzyme inhibition kinetics and SAM/1-MNA substrate balance

• NAD+ and SAM level changes in adipocyte and hepatocyte cell models

• Lipogenesis suppression in 3T3-L1 differentiated adipocyte assays

• Polyamine flux enzyme upregulation (ODC, SSAT) and histone methylation

• In vivo efficacy in diet-induced obesity (DIO) murine models

QUICK SPECS

• Form: Lyophilized powder

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: -20°C recommended, protect from light and moisture

• Note: Supplied as iodide salt form. Not reconstituted in bacteriostatic water — consult protocol for appropriate solvent system.

IDENTITY BASICS

• Chemical Name: 5-amino-1-methylquinolinium iodide

• Molecular Formula: C₁₀H₁₁N₂⁺ (free base); C₁₀H₁₁IN₂ (iodide salt)

• Molecular Weight: 159.21 g/mol (free base); 286.11 g/mol (iodide salt)

• CAS Number: 42464-96-0

• PubChem CID: 950107

• Class: Small-molecule NNMT inhibitor (NOT a peptide)