KPV Peptide Canada

KPV Peptide Canada, a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). Studied for anti-inflammatory signaling, NF-κB pathway modulation, and intestinal barrier function research. 10mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment (residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH), one of the most studied endogenous anti-inflammatory peptides. Unlike full-length α-MSH, KPV retains anti-inflammatory signaling activity without melanocortin receptor-mediated pigmentation effects. Research has shown that KPV enters cells via the PepT1 di/tripeptide transporter and directly modulates intracellular NF-κB and MAP kinase signaling pathways. It has been studied extensively in gastrointestinal inflammation models including DSS and TNBS colitis. Durham Peptides also carries BPC-157, another peptide studied in gastrointestinal research contexts.

BENEFITS/KPV Peptide Canada

• Anti-inflammatory signaling — studied for NF-κB and MAPK pathway inhibition at nanomolar concentrations

• Intestinal barrier research — explored for mucosal protection and epithelial barrier function

• Pigmentation-free — retains α-MSH anti-inflammatory activity without melanocyte stimulation

• PepT1-mediated transport — studied for intracellular uptake via the di/tripeptide transporter

• Antimicrobial research — investigated for effects against S. aureus and C. albicans in preclinical models

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: Lys-Pro-Val (tripeptide)

• Molecular Formula: C₁₆H₃₀N₄O₄

• Molecular Weight: 342.43 g/mol

• CAS Number: 67727-97-3

• Common Synonyms: ACTH(11-13), α-MSH(11-13), KPV Tripeptide