PT-141 Canada (Bremelanotide) — 10mg

PT-141 Canada (Bremelanotide), a synthetic cyclic heptapeptide melanocortin-receptor agonist (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) derived from the α-MSH fragment. Studied for activation of melanocortin receptors (MC4R/MC1R) and central nervous system signaling pathways in research models. 10mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

PT-141, also known as bremelanotide, is a cyclic analog of the melanocortin peptide Melanotan II, developed as a non-selective agonist at melanocortin receptors with particular activity at MC4R and MC1R. Unlike its parent compound, bremelanotide acts primarily through central melanocortin pathways rather than peripheral pigmentation pathways, making it a frequent subject in neuroendocrine and behavioral research. The lactam bridge between the Asp and Lys residues constrains the peptide into its bioactive conformation.

BENEFITS/PT-141 Canada

• Melanocortin signaling — studied for agonist activity at MC4R and MC1R receptors

• Central pathway research — investigated for centrally-mediated effects distinct from peripheral pigmentation

• Cyclic stability — lactam-bridged structure constrains the bioactive conformation

• α-MSH derived — retains the core melanocortin pharmacophore

• Well-characterized — extensively referenced melanocortin research peptide

WHAT RESEARCHERS LOOK AT

• Melanocortin receptor (MC4R, MC1R) binding and activation

• Central nervous system melanocortin signaling pathways

• Behavioral and neuroendocrine research models

• Receptor selectivity profiling versus other melanocortin analogs

• Structure–activity relationships of the cyclic lactam scaffold

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH (cyclic heptapeptide)

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀

• Molecular Weight: 1025.18 g/mol

• CAS Number: 189691-06-3

• Common Synonyms: Bremelanotide, PT-141