CJC-1295 (No DAC)

CJC-1295 (No DAC), a synthetic 30-amino-acid GHRH analog also known as Modified GRF (1-29). Studied for short-acting growth hormone-releasing hormone receptor activation and pulsatile GH secretion patterns. 10mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

CJC-1295 (No DAC), also known as Modified GRF (1-29), is a synthetic 30-amino-acid analog of growth hormone-releasing hormone (GHRH). It contains four strategic amino acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) that enhance enzymatic stability over native GHRH (1-29) / Sermorelin while retaining a short half-life of approximately 30 minutes. This pulsatile profile distinguishes it from CJC-1295 with DAC (Drug Affinity Complex), which has an extended ~6-8 day half-life via albumin binding. The “No DAC” variant is widely used in research models examining short-acting GHRH analog activity, frequently paired with Ipamorelin for combined GHRH/GHS pathway research.

BENEFITS/CJC-1295

• GHRH receptor binding — studied as a stabilized GHRH analog with enhanced enzymatic resistance

• Pulsatile profile — short half-life (~30 min) preserves natural GH release patterns

• Stack compatibility — commonly paired with Ipamorelin in dual-pathway GH research

• Modified GRF identity — well-documented in published GHRH literature

• Research convenience — single 10mg vial for extended research protocols

WHAT RESEARCHERS LOOK AT

• Pulsatile growth hormone release in pituitary cell models

• IGF-1 secretion patterns following GHRH analog administration

• Comparative half-life studies vs. native GHRH (1-29) and CJC-1295 (DAC)

• Synergy with ghrelin receptor agonists like Ipamorelin

• Bone density and longitudinal growth research models

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

• Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂

• Molecular Weight: 3367.9 g/mol

• CAS Number: 446036-97-1

• PubChem CID: 91976842

• Common Synonyms: Modified GRF (1-29), CJC-1295 (No DAC), GHRH (1-29)-NH₂