NAD+ — 500mg

Research-grade NAD+ (nicotinamide adenine dinucleotide, oxidized form), a coenzyme central to cellular energy metabolism, redox signaling, and sirtuin-mediated longevity pathways. 500mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for over 500 enzymatic reactions including cellular respiration, DNA repair, and gene expression. It serves as a critical electron carrier in mitochondrial oxidative phosphorylation and is the primary substrate for sirtuin enzymes (SIRT1-7) and PARP enzymes involved in DNA damage response. Research interest in NAD+ has expanded dramatically due to observations that intracellular NAD+ levels decline with age, correlating with metabolic dysfunction in preclinical aging models. Durham Peptides also carries 5-Amino-1MQ, a small molecule NNMT inhibitor studied for its role in NAD+ salvage pathway modulation.

BENEFITS

• Energy metabolism — essential cofactor in glycolysis, the TCA cycle, and oxidative phosphorylation

• Longevity research — required substrate for sirtuin enzymes (SIRT1-7) studied in aging

• DNA repair — consumed by PARP enzymes during poly(ADP-ribose)ylation of damaged DNA

• Redox biology — central electron carrier in cellular NAD+/NADH redox balance

• Broad research utility — applicable across metabolic, aging, neurological, and mitochondrial research

WHAT RESEARCHERS LOOK AT

• NAD+/NADH ratio changes in metabolic disease and aging models

• Sirtuin-dependent deacetylation and gene silencing pathways

• PARP-mediated DNA repair responses and NAD+ depletion in cellular stress

• Mitochondrial bioenergetics and Complex I electron transport

• NAD+ supplementation effects on cellular senescence markers

QUICK SPECS

• Form: Lyophilized powder

• Net per vial: 500 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: -20°C recommended, protect from light and moisture

• Reconstitution: Use bacteriostatic water or sterile water (sold separately)

IDENTITY BASICS

• Full Name: Nicotinamide adenine dinucleotide (oxidized form)

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂

• Molecular Weight: 663.43 g/mol

• CAS Number: 53-84-9

• PubChem CID: 5893

• Note: NAD+ is a dinucleotide coenzyme, not a peptide. It is carried alongside research peptides due to its relevance in metabolic and longevity research protocols.