AOD-9604 Canada

AOD-9604 Canada, a synthetic 16-amino-acid peptide fragment (Tyr-hGH 176-191) derived from the C-terminal domain of human growth hormone. Studied for selective lipolytic activity, adipose metabolism, and fat cell signaling independent of IGF-1 receptor activation. 5mg lyophilized powder, 99%+ purity verified by Janoshik Analytical via HPLC and mass spectrometry.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic hexadecapeptide corresponding to residues 176-191 of human growth hormone, with a tyrosine substitution at the N-terminus and an intramolecular disulfide bridge (Cys7-Cys14). Originally developed by Metabolic Pharmaceuticals Ltd. in Australia during the 1990s, AOD-9604 was designed to isolate growth hormone’s lipolytic properties while excluding the broader metabolic and growth-promoting effects associated with full-length hGH. It completed six human clinical trials involving over 900 participants. AOD-9604 is frequently studied alongside Durham Peptides’ metabolic research compounds including Semaglutide and Tirzepatide.

BENEFITS/AOD-9604 Canada

• Selective lipolytic activity — studied for fat metabolism independent of IGF-1 receptor activation

• Growth hormone fragment — retains the hGH 176-191 lipolytic region without somatotropic effects

• Disulfide-stabilized — Cys7-Cys14 bridge provides conformational stability

• Extensive clinical history — studied in over 900 human subjects across Phase I-IIb trials

• Distinct mechanism — operates independently of the hGH receptor

WHAT RESEARCHERS LOOK AT

• β₃-adrenergic receptor upregulation in adipocyte models

• Lipolysis and lipogenesis inhibition in white and brown adipose tissue

• Comparative analysis vs. full-length hGH on lipolytic activity

• IGF-1 independence and selective metabolic effects

• Cartilage regeneration and joint biology in preclinical models

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 5 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide: Cys7-Cys14)

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

• Molecular Weight: 1,815.12 g/mol

• CAS Number: 221231-10-3

• PubChem CID: 71300630

• Common Synonyms: Tyr-hGH Fragment 176-191, HGH Frag 176-191, Lipotropin